Cnidium Monnieri Extract

Introduction of Cnidium Monnieri extract：

Cnidium Monnieri is a flowering plant belonging to the Apiaceae (carrot) family, native to China, Vietnam, and other parts of Asia. In Traditional Chinese Medicine (TCM), its dried fruit, known as She Chuang Zi (蛇床子), has been used for centuries.

The modern Cnidium Monnieri extract is a concentrated form derived from these fruits, standardized for its key bioactive compounds, most notably:

• Osthole: This is considered the primary active coumarin responsible for most of the extract’s renowned benefits.

• Other coumarins: Such as imperatorin, bergapten, and xanthotoxin.

In TCM, it is categorized as a herb that warms the Kidneys, strengthens Yang, and dispels dampness and wind. It was traditionally used for skin conditions, gynecological issues, and to support male vitality.

Benefit of Cnidium Monnieri extract:

Modern scientific research has focused on validating and explaining its traditional uses, with osthole being the most studied component.

1. Natural Support for Male Sexual Health (Most Famous Benefit)

• How it works: This is the most celebrated use of Cnidium extract.

  • PDE-5 Inhibition: Osthole acts as a natural, mild inhibitor of the enzyme phosphodiesterase type 5 (PDE-5). This is the same mechanism behind drugs like Viagra, but in a milder, more natural form. It helps relax smooth muscle tissue and promote blood flow.

  • Hormonal Influence: Some studies suggest it may support healthy testosterone levels by influencing the hypothalamic-pituitary-gonadal axis.

• Benefit: Primarily used to support erectile function, improve libido (sex drive), and enhance overall sexual performance naturally.

2. Skin Health and Anti-Psoriasis Effects

• How it works: Osthole possesses significant anti-inflammatory and anti-proliferative properties. It helps calm skin inflammation and slows down the excessive skin cell growth that characterizes conditions like psoriasis and eczema.

• Benefit: Topical applications of Cnidium extract are effective in relieving itching, reducing scaling, and calming psoriatic plaques. It is a common ingredient in TCM formulas for various itchy skin conditions (antipruritic).

3. Antioxidant and Anti-Inflammatory Properties

• How it works: Osthole is a potent antioxidant that scavenges free radicals. It also inhibits the production of pro-inflammatory cytokines (like TNF-α and IL-6), reducing systemic inflammation.

• Benefit: Helps protect cells from oxidative stress, which is linked to aging and chronic diseases. Its anti-inflammatory effect supports its use for arthritis and other inflammatory conditions.

4. Bone Health Support (Osteoporosis Prevention)

• How it works: Research indicates that osthole can stimulate bone formation and inhibit bone resorption (breakdown). It appears to promote the activity of osteoblasts (bone-building cells).

• Benefit: Shows great potential as a natural therapeutic agent for preventing and treating osteoporosis, especially in postmenopausal women.

5. Antifungal and Antimicrobial Activity

• How it works: The extract, particularly osthole, has demonstrated broad-spectrum activity against various fungi (e.g., Candida albicans, Trichophyton species that cause athlete’s foot) and bacteria.

• Benefit: Supports its traditional use for treating vaginal yeast infections, jock itch, and other fungal skin infections. It is often used in topical washes and powders.

6. Neuroprotective Effects

• How it works: Preliminary studies suggest that osthole may protect neurons from damage and improve cognitive function. It may help regulate neurotransmitters and protect against toxins.

• Benefit: Potential future applications in supporting brain health and protecting against neurodegenerative diseases like Alzheimer’s, though more research is needed.

Summary of Benefits Table

Dosage and Safety Considerations

• Dosage: There is no universally established dose. Supplements typically provide 50-200 mg of a standardized extract (often standardized to 5-10% osthole) per serving. Always follow the product’s specific dosage instructions.

• Safety: Generally well-tolerated at recommended doses.

• Side Effects: Rare, but may include mild digestive upset or dry mouth. Due to its effect on blood flow, it may cause dizziness in some individuals.

• Important Considerations:

  • Pregnancy & Breastfeeding: Contraindicated. It may stimulate uterine contractions.

  • Hormone-Sensitive Conditions: Because of its potential hormonal effects, individuals with prostate cancer, endometriosis, or uterine fibroids should avoid it unless approved by a doctor.

  • Surgery: Due to its potential to affect blood pressure and blood clotting, discontinue use at least 2 weeks before scheduled surgery.

  • Drug Interactions: May theoretically interact with blood pressure medications, blood thinners (like warfarin), and PDE-5 inhibitor drugs (like Viagra). Consult a healthcare provider if you are on medication.

Conclusion:
Cnidium Monnieri extract is a powerful natural remedy with a strong history in TCM, now supported by modern science. Its wide range of benefits, from enhancing male sexual health and treating skin conditions to supporting bone density, is primarily driven by its key compound, osthole. While promising, it is a potent extract that should be used with knowledge and caution, particularly regarding its contraindications for certain health conditions and potential medication interactions. Consulting a healthcare professional before use is highly recommended.

Packing of Cnidium Monnieri extract:

25kg/ドラム、紙ドラムと二重のビニール袋で梱包。

Storage of Cnidium Monnieri extract:

湿気、光、酸素を避けて、密閉容器で保管すること。

Shelf life of Cnidium Monnieri extract:

上記の条件下で、オリジナルのパッケージで24ヶ月間。