Agrimonia Pilosa Ledeb Extract

Introduction to Agrimonia Pilosa Ledeb Extract

Agrimonia pilosa Ledeb is a perennial herb belonging to the Rosaceae (rose) family. It is widely distributed across East Asia, including China, Korea, and Japan. In Traditional Chinese Medicine (TCM), it is known as Xian He Cao (仙鹤草), which translates to “Immortal Crane Herb,” a name that hints at its highly valued therapeutic properties.

The aerial parts (whole plant) are used to create the extract, which is rich in a diverse range of bioactive compounds, including:

• Tannins (e.g., agrimoniin – a potent ellagitannin)

• Flavonoids (e.g., luteolin, quercetin, apigenin)

• Triterpenes

• Phenolic acids

• Volatile oils

For centuries, it has been a cornerstone herb in TCM for its hemostatic (blood-stopping) and anti-dysentery effects. Modern scientific research has now expanded our understanding of its mechanisms and benefits, validating many of its traditional uses.

Key Benefits of Agrimonia Pilosa Ledeb Extract

The extract’s benefits are largely attributed to its high concentration of tannins and flavonoids, which impart strong astringent, antioxidant, and anti-inflammatory properties.

1. Hemostatic Agent (Stops Bleeding)

• How it works: This is its most classic traditional use. The tannins promote blood coagulation by precipitating proteins, which helps to form a protective layer and constrict blood vessels at the site of bleeding.

• Benefit: Used both topically and internally to manage bleeding. It is effective for nosebleeds, bleeding gums, heavy menstrual bleeding (menorrhagia), and bleeding in the digestive tract (e.g., ulcers, hemorrhoids).

2. Antimicrobial and Anti-Dysentery

• How it works: The extract demonstrates broad-spectrum activity against various pathogens, including bacteria (Staphylococcus aureus, E. coli, サルモネラ菌), fungi, and parasites (like Entamoeba histolytica, which causes amoebic dysentery).

• Benefit: Traditionally used to treat infectious diarrhea, dysentery, and intestinal inflammation. It helps eliminate the causative pathogen while reducing intestinal inflammation.

3. Anti-Inflammatory and Antioxidant Effects

• How it works: The flavonoids and tannins are powerful antioxidants that scavenge free radicals. They also inhibit the production of key pro-inflammatory cytokines (e.g., TNF-α, IL-6), reducing systemic inflammation.

• Benefit: Helps protect cells from oxidative stress, which is linked to aging and chronic diseases. Its anti-inflammatory action supports its use in relieving inflammatory conditions, including arthritis and gastritis.

4. Anti-Cancer Potential

• How it works: Preclinical studies (in vitro and in animal models) have shown that agrimoniin and other compounds can induce apoptosis (programmed cell death) in cancer cells, inhibit angiogenesis (growth of new blood vessels to tumors), and suppress tumor proliferation. It appears to be particularly studied for leukemias and gastrointestinal cancers.

• Benefit: While not a cure, this research suggests a strong potential for Agrimonia pilosa extract as an adjunctive therapy in cancer treatment and prevention. More human clinical trials are needed.

5. Antidiabetic Effects

• How it works: Studies indicate that the extract can inhibit the enzymes α-glucosidase and α-amylase, which are responsible for breaking down carbohydrates into glucose in the gut. This slows down glucose absorption after a meal.

• Benefit: Helps moderate blood sugar levels, making it a promising natural adjunct for managing type 2 diabetes.

6. Gastroprotective Properties

• How it works: Its anti-inflammatory, antioxidant, and astringent properties work together to protect the stomach lining. It helps reduce gastric acid secretion and heal ulcers.

• Benefit: Effective in supporting the treatment of gastric and duodenal ulcers.

Summary of Benefits Table

Dosage and Safety Considerations

• Dosage: There is no universally established dose. In traditional decoctions, 10-15 grams of the dried herb is commonly used. For extracts, dosage can vary widely based on concentration and standardization. Always follow the product’s specific dosage instructions or consult a TCM practitioner.

• Safety: Generally considered safe when used appropriately.

• Side Effects: Due to its high tannin content, excessive doses may cause digestive upset, constipation, or impair the absorption of certain minerals (like iron).

• Important Considerations:

  • Pregnancy and Breastfeeding: Safety has not been established. Avoid use.

  • Drug Interactions: May interact with diabetes medications (potentiating their effect and increasing hypoglycemia risk) and blood thinners (like warfarin). Due to its effect on blood coagulation, it should not be used concurrently with anticoagulant/antiplatelet drugs without medical supervision.

  • Underlying Conditions: Individuals with iron deficiency anemia should use with caution due to potential absorption interference.

Conclusion:
Agrimonia Pilosa Ledeb Extract is a multifaceted herb with a profound history in TCM. Modern science has successfully illuminated the mechanisms behind its traditional uses, such as stopping bleeding and treating dysentery, while also uncovering exciting new potential in areas like cancer adjunct therapy and diabetes management. Its power is derived from its complex mixture of astringent tannins and antioxidant flavonoids. As with any potent therapeutic agent, it should be used knowledgeably and under guidance, especially given its potential to interact with medications.